Preheat oven to 350 degrees F.
Line a baking sheet with foil or parchment paper.
Heat olive oil in a small skillet over medium-high heat. Add Panko and cook until browned, stirring frequently, about 3 minutes. Transfer to a bowl and set aside.
In a medium bowl, cream together cream cheese, cheddar, garlic and onion powders, salt and pepper.
Spoon the filling into each jalapeño cavity. Place on prepared baking sheet, filled side up, and bake until the filling is runny and golden, about 15 - 20 minutes.
Sprinkle with the toasted Panko and serve immediately.